With the 2016 election cycle heating up and endorsements coming in daily, several major bands have announced that they will be “Feeling The Bern” when they perform at upcoming rallies in Iowa and Los Angeles in support of Senator Bernie Sanders and his campaign for President. This Saturday, January 30 at the University of Iowa Fieldhouse, supporters will be treated to performances by vocal Sanders supporter Killer Mike, a newly revamped Vampire Weekend, and Foster The People.The following Friday, February 5 will see the Red Hot Chili Peppers play at the Los Angeles’ Theatre at the Ace Hotel for a “FEEL THE BERN” benefit. Tickets are available through AXS and will start at $30, running all the way up to $2700. Tickets will be available after 1 PM Eastern, according to Loudwire.Tickets are also available for people contributing to Bernie Sanders Campaign here.Members Of Phish, Red Hot Chili Peppers & Wilco Among Those To Sign Letter Endorsing Bernie SandersIn other news, RHCP drummer Chad Smith posted on Facebook several days ago that the band had just recorded a new track from top to bottom in four hours for the upcoming album, so be sure to be on the lookout for more updates from the Chili Peppers.
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Researchers better understand biological clock
Researchers at Harvard University and the Howard Hughes Medical Institute (HHMI) have discovered that a simple circadian clock found in some bacteria operates by the rhythmic addition and subtraction of phosphate groups at two key locations on a single protein. This phosphate pattern is influenced by two other proteins, driving phosphorylation to oscillate according to a remarkably accurate 24-hour cycle.Writing this week in the journal Science, the scientists describe what causes a trio of proteins, if placed in a test tube with the common biochemical fuel ATP as a source of phosphate, to function as a minimalist biological clock of sorts, maintaining an accurate circadian rhythm for long periods of time.The new Harvard work builds upon research reported in 2005 by biologist Takao Kondo and colleagues at Nagoya University in Japan. That team initially reported that a circadian clock could be reconstituted in a test tube solely with three proteins and ATP.“The most striking feature of this circadian oscillator is its precision,” says Erin K. O’Shea, professor of molecular and cellular biology and chemistry and chemical biology in Harvard’s Faculty of Arts and Sciences (FAS), director of the FAS Center for Systems Biology, and Howard Hughes Medical Institute investigator. “Even in the absence of external cues — in total darkness — these minuscule protein-based clocks can maintain precision to a small fraction of a day over several weeks.”O’Shea, postdoctoral researcher Michael J. Rust, graduate student Joseph S. Markson, and colleagues studied circadian rhythms in cyanobacteria, better known as blue-green algae. These simple organisms, responsible for some 70 percent of the Earth’s photosynthesis, devote most of their energies toward just two biological processes: photosynthesis and reproduction.The scientists scrutinized the activity of three bacterial proteins known as KaiA, KaiB, and KaiC. They found that during the daytime, KaiC is cyclically phosphorylated at two amino acid residues: first at a specific threonine, and then at a specific serine. During nighttime hours, the two amino acids are dephosphorylated in the same order.The KaiA protein promotes the phosphorylation of KaiC, and KaiB, sensing one of the phosphorylated forms of KaiC, blocks KaiA’s activity, creating an intricate biochemical dance that results in a nearly perfect 24-hour oscillation. The researchers’ subsequent mathematical analysis confirmed that this distinctive dynamic would, in fact, reproduce a circadian period.The bacterial proteins studied by O’Shea, Rust, Markson, and colleagues are not known to exist in humans, but the researchers say their findings illuminate general feedback mechanisms that could serve to establish chronological oscillations in a whole host of organisms.“It’s unknown whether such a mechanism is at the core of all circadian clocks,” says Rust, a postdoctoral researcher in Harvard’s Department of Molecular and Cellular Biology. “It’s the simplest chemical oscillator known, and we are looking at it as a possible model for other species.”O’Shea says the 2005 finding by Kondo and colleagues that a cyanobacterial circadian clock could be recreated in a test tube using only three proteins and ATP surprised researchers because it showed that some circadian rhythms are driven solely by protein-protein interactions.“It demonstrated that circadian clocks can operate independently of DNA and most cellular components, contradicting the previous prevailing theory that an entire organism was likely needed to maintain a clock,” she says.O’Shea, Rust, and Markson’s co-authors are William S. Lane at Harvard and Daniel S. Fisher at Stanford University. The research was sponsored by HHMI and the National Science Foundation.steve_bradt@harvard.edu
Non-Chemo Cancer Treatment, Simple as Flu Shot, Moves Closer to Reality
AddThis Sharing ButtonsShare to FacebookFacebookFacebookShare to TwitterTwitterTwitterShare to EmailEmailEmailShare to RedditRedditRedditShare to MoreAddThisMoreImagine treating cancer as easily as taking a monthly shot in the arm.Doctors in Texas have been cleared to move forward with another round of human trials on a “cancer vaccine” that turns a deadly disease into a chronic one that can be more easily treated — allowing patients to live far longer.It’s a form of immunotherapy that eliminates the need for chemotherapy and other difficult treatments — allowing cancer to be treated like diabetes or hypertension.CHECK Out: Asthma Could Be Cured Within 5 Years With This New Breakthrough“We don’t cure, but we control the disease,” Dr. Maurizio Ghisoli told KTVT News.The immune system doesn’t recognize cancer cells on its own, so it needs outside help to attack the disease. With this particular type of immunotherapy, doctors create a personal shot for each patient. They take cells from the patient’s tumor, modify them so the immune system can attack the cancer, then re-inject the cells back into the body.RELATED: Cancer Cells Self-Destruct With New Therapy, Patients Live LongerMonthly doses allow the immune system to keep cancer growth in check.Researchers at Baylor Hospital in Dallas, Texas have been working on the experimental treatment for two decades. They have used it to control a wide range of cancers including throat and ovarian cancer and Ewing’s Sarcoma, a fast-spreading bone cancer that typically targets children, teens, and young adults.CHECK OUT: Science Just Saved A Baby, Beating Cancer With Untested, Last TryThe U.S. Food and Drug Administration recently approved more extensive human trials on the Baylor treatment and the “cancer vaccine” could be available in four to five years.WATCH the 2016 video at KTVT News. (Photo: CDC)Give Your Friends A Shot of Hope, Share This…AddThis Sharing ButtonsShare to FacebookFacebookFacebookShare to TwitterTwitterTwitterShare to EmailEmailEmailShare to RedditRedditRedditShare to MoreAddThisMore
Virginia Colletti
Virginia was a Eucharistic Minister at St. James Catholic Church and a member of the Altar Society and the Serra Club.She loved to travel with her late husband and enjoyed her family.Virginia was born on August 23, 1919 in Salaparuta, Italy to Joseph and Sarah Corte. Entombment will follow at Greenlawn Memorial Park in Groves, Texas.Mrs. Colletti was preceded in death by her husband, Victor of 56 years and her son, Victor James.She is survived by her daughters, Roseanne Harris of Old Tappan, New Jersey, Sarah Colletti and her husband Roger Baker of Houston, Texas, sons, Laurence Colletti of Denver, Colorado and Chris Colletti and his wife Susan of Cedar Park, Texas; seven grandchildren, Laurence Colletti, Sarah Reynolds and husband Matt, Ashleigh Colletti and her husband David Colwill, Meaghan Colletti, Christina Colletti, Victoria Harris, Jordan Baker; great grandchildren, Chance and Vivian Reynolds. Virginia Colletti, 100, of Houston and formerly of Port Arthur passed away on Monday, February 10, 2020, at Brookdale Senior Living in Houston, Texas.Virginia was one of the founders of the Italian American Cultural Society of Southeast Texas and taught Italian lessons.She was an officer in the Department Club.
Her family immigrated to the United States when she was three, settling in New Orleans.She graduated from the Dominican College with a Bachelor of Science Degree in Home Economics and became a school teacher.She married Victor Colletti of Port Arthur where they raised their family.A visitation will take place from 12:00 p.m. until 2:00 p.m. Friday, February 14, 2020, at St. James Catholic Church with a Mass of Christian Burial to immediately follow at 2:00 p.m. Friday at thechurch.
Will Oprah Winfrey Bring John Doyle’s Revamped Revival of The Color Purple to Broadway?
Talk show mogul Oprah Winfrey recently discussed her dreams of making her Broadway debut, and now she could be producing a newly imagined musical adaptation of The Color Purple on the Great White Way, according to The New York Times. Director John Doyle’s streamlined production is currently playing at the 190-seat Menier Chocolate Factory in London, where it is scheduled to run through September 14. In addition to Broadway, Winfrey and producer Scott Sanders are reportedly making preliminary plans to open the musical in both the West End and Africa. No theater or dates have been announced. Based on the novel by Alice Walker, The Color Purple tells the story of Celie, a woman who, through love, finds the strength to triumph over adversity and discovers her voice in the world. The original Broadway production was directed by Gary Griffin, and starred Brandon Victor Dixon, Renee Elise Goldsberry and LaChanze, who won a Tony Award for her portrayal of Celie. Winfrey was nominated for an Oscar for her performance as Sofia in the 1985 film adaptation of The Color Purple and was part of the producing team for the original Broadway production. Featuring a book by Marsha Norman, lyrics by Brenda Russell, Allee Willis and Stephen Bray and music by Russell and Willis, The Color Purple opened December 1, 2005, at the Broadway Theatre, where it played through February 24, 2008. During its run, the musical recouped its $11 million investment. The new staging cuts approximately 30 minutes of material from the original production.
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Jeremy Kushnier Will Return to Footloose in New Role & More 2019 Muny Casting
The Muny has announced an exciting group of Broadway stars set to appear in productions as part of its 2019 summer season. The previously announced slate of works will run from June 10 through August 11 at the St. Louis outdoor theater.The season opener, Guys and Dolls (June 10-16), will star Jordan Gelber (Avenue Q) as Nathan Detroit, Kendra Kassebaum (Come From Away) as Miss Adelaide, Ben Davis (Call Me Madam) as Sky Masterson and Brittany Bradford (Merrily We Roll Along) as Sarah Brown.Taylor Louderman, Tony-nominated star of Mean Girls, will return to the role of Kinky Boots’ Lauren in the Muny’s new staging of the high-heeled hit (June 19-25) alongside fellow former Broadway star J. Harrison Ghee (The Sting) as Lola. Graham Scott Fleming (Miss Saigon) will join them as Charlie Price.The Muny’s fresh staging of 1776 (June 27-July 3) will feature Robert Petkoff (Fun Home) as John Adams, Adam Heller (Popcorn Falls) as Benjamin Franklin and Keith Hines Jr. (Jersey Boys) as Thomas Jefferson.Cinderella (July 8-16) will star Mikaela Bennett (The Golden Apple) in the title role alongside Jason Gotay (Call Me Madam) as Prince Topher. Co-starring will be Ashley Brown (Mary Poppins) as Marie and Vicki Lewis (Anastasia) as Madame.Footloose (July 18-24) will feature Jeremy Kushnier (Head Over Heels), who originated the role of Ren in the 1998 original Broadway production, graduating to the role of Reverend Shaw Moore. He’ll appear alongside Mason Reeves (A Chorus Line) as Ren and McKenzie Kurtz (Sweet Charity) as Ariel Moore.Mamie Parris (School of Rock) will star as Cayla Woodling in Paint Your Wagon (July 27-August 2), alongside Matt Bogart (Jersey Boys) as Ben Rumson, Mark Evans (I Married an Angel) as William and Omar Lopez-Cepero (The Flamingo Kid) as Armando.The closing production, Matilda (August 5-11) will feature Tony nominee Will Swenson (Waitress) as Miss Trunchbull, Ann Harada (I Married an Angel) as Mrs. Wormwood, Josh Grisetti (Something Rotten!) as Mr. Wormwood and Laura Michelle Kelly (The King and I) as Miss Honey.Further casting and creative team members for the Muny’s 2019 summer season will be announced soon. Jeremy Kushnier(Photo: Emilio Madrid-Kuser for Broadway.com) View Comments
CELTMAN! Extreme Scottish Triathlon
A new extreme event for Scotland is coming soon. The CELTMAN! Extreme Scottish Triathlon will take place on 23 June 2012 in Wester Ross, Scotland. Centred around the stunning Torridon mountains, according to the event organisers, CELTMAN! ‘will take you on an adventure unlike any other.’CELTMAN! is a long distance extreme triathlon. As the organisers mention in their pre-race summary…Please take note – this race is HARD. The distances are Ironlike and the terrain severe. You will be expected to complete a sea-loch swim, an arduous cycle and a mountainous run. This will require endurance, stamina, great bike handling skills and off-road running experience.’Please do not enter this race if you question your own ability to do anything mentioned above.The route, for the moment, remains under wraps – but you will not be disappointed. Expect this to be one of the hardest days of your life.Entries will open on 5 November and numbers will be restricted to 150 for the first year of the race. Each athlete will require a support car/crew. One of the crew must be fit and able enough to accompany the competitor during the last leg of the run over a large mountain!Athletes will need to be in Torridon, Scotland at least the day before the race (22 June 2012). Torridon is remote village and is at least 5 hours drive from Glasgow or Edinburgh. To register interest in the inaugural CELTMAN! race, athletes should email paul[at]durtyevents.com. Entry details will be sent out as soon as they are available along with other relevant updates.For sponsorship information or enquiries, interested parties can e-mail stuart[at]thetricentre.com.www.cxtri.com Related
Plans for ‘Uptown Row’ development announced
Phoenix-based residential real estate developer Boxwell Southwest, in partnership with award-winning designers The Ranch Mine, released plans for “Uptown Row,” a modern residential community in North Central Phoenix near 7th Avenue and Camelback Road. Set for completion in April 2016, construction of Uptown Row is currently underway.“What sets Uptown Row apart from other urban living developments is the innovative indoor-outdoor lifestyle,” said Boxwell Southwest president, Evan Boxwell. “With standard features like a private courtyard and rooftop patio terrace, each home blends the lines of where the indoors starts and the outdoors ends to provide residents with the best of Phoenix’s incredible climate and views in an open and spacious setting.”Located in the heart of Pierson Place Historic District, Uptown Row will feature 10 modern, row-style townhomes, each with its own private courtyard and spacious, 20 ft. x 20 ft. rooftop terrace with views of the mountains and/or the city skyline. The three-story residences are available in 2-bedroom + den or3-bedroom + office and den floor plans ranging in size from 1,651 square feet for a Pierson unit (2-bedroom floor plan) to 2,057 square feet for an Avenue unit (3-bedroom floor plan). Both the Pierson and Avenue options include 2.5 baths and a spacious 2-car garage.Uptown Row’s modern architecture is complemented by sleek design finishes including quartz, waterfall countertops, concrete and wood-tiled floors, stainless steel appliances, 10′ ceilings, floor-to-ceiling stackable, glass sliders at courtyard and rooftop terrace, and an open floor plan with ample natural daylight.Uptown Row is positioned within walking and biking distance to some of the best locally-owned restaurants, bakeries, cafes, farmer’s markets and coffee spots in all of the North Central Corridor. Steps from the light rail station at 7th Avenue and Camelback, Uptown Row is minutes from downtown Phoenix, its dining and nightlife scene and entertainment options like sports arenas, concerts, museums and galleries.Boxwell Southwest has selected Realty Executives’ Caniglia Group as its exclusive selling agent to market Uptown Row. The team of Shelley Caniglia, Steve Caniglia and Erik Jensen have begun facilitating tours of the development to prospective buyers during construction and sales are officially underway. Builder and lender incentives are also available.
In spite of everything, Valamar is successfully developing sports tourism
In the period from January 26 to 29, the Valamar Diamant Hotel simultaneously hosts as many as 12 sports clubs from many European countries, reports Valamar.Namely, two international sports tournaments are taking place in Poreč at the same time, which will gather a hundred professional athletes: the handball tournament “Memorial Darko Pupovac”, which is traditionally held every year at this time, and the indoor soccer tournament “2. Winter Cup “. “Hotel Valamar Diamant is highly valued in the sports world for its excellent conditions for fitness training of athletes. In addition to comfortable accommodation and excellent nutrition, it offers athletes a polyvalent sports hall within the hotel, indoor pools and fitness, aerobics and wellness center. Valamar Diamant also hosted the handball teams of the 21st World Handball Championship (Brazil, Denmark, Egypt, Norway, Saudi Arabia and Serbia) and the teams of Tunisia, Algeria and Russia during the President’s Cup. ” said Davor Brenko, vice president of sales and marketing at Valamar Riviera.In addition to the home team, Valamar will host teams from Austria, Hungary, Belgium, Slovakia, Slovenia and France in just three days. “Last year, he was chosen for the preparations by the multiple champion of Hungary and one of the best European handball teams – Telekom Veszprem and our most trophy-winning handball club PPD Zagreb. The destination itself and the top service in the hotel delighted many so much that they come back to us regularly, not only for business, but also privately.. ”Brenko points out.In addition to the multipurpose sports hall, the Valamar Diamant Hotel offers a state-of-the-art fitness center with more than 40 Technogym equipment. Also, since the autumn of last year, the Valamar Diamant Hotel has become the first hotel in Croatia to introduce a certificate Healthy Meal Standard, which targets guests with specific nutritional needs, habits and desires, and especially athletes.It is still possible, but without a strategy at the State level there is no long-term success.This is a positive example of how one can succeed in spite of everything and how he had a great opportunity and potential to develop sports tourism, but this is unfortunately only the success of an individual, in this case Valamar, and not that it is strategically and planned at the state level. . It’s more like it was stopped as planned. Of course, we are talking about Valamar, which has logistical, financial and accommodation possibilities and is forced to invest on its own in order to extend its tourist season. And what about others? It all comes down to certain proactive individuals as organizers of sporting events which is not the result of a strategic and long-term vision or development. So, as in everything without strategic and planned development, there is no long-term success. Everything is focused on cities and counties that do not have a vision or strategy for the development of local sports.The biggest misconception is that sports tourism is tied only In addition to football, there is no opportunity in small sportsThe development of sports tourism is not based only on football, it is an opportunity for “small” sports. Here is just one plastic example… There are currently over 50 million runners in Europe and the number of runners is growing day by day. We are talking about amateurs, not professionals, who run marathons, and most often they are business people who generate over 9 billion Euros of revenue each year to hotels, carriers and race organizers. Smart enough. Sport and tourism have always gone and will always go together, and every event, whether small or large is just a plus and an additional cube in the mosaic of sports tourism development.As Davor Brenko points out, success and performance levels generate tourist arrivals on a private basis, ie we turn business clients into private ones. The answer to the question of how to extend the season through the pre- and post-season is simple: Content, content and content. Sports tourism is certainly one of the elements and recipes for extending the season, but like everything else – we have to deal with the development of sports tourism.Golf tourism development: Yes or no?There has been a debate for years whether golf tourism should be added to our tourism. Unfortunately the debate is going in the wrong direction. It is not at all questionable whether we need golf courses, we absolutely need them, the only question is in which locations and how to fit it into a complete tourist product. Of course, golf tourism should be viewed through the prism of additional services and values, and not as the main motive for coming. But while we’ve only been thinking and talking about it for ten years, the competition isn’t sleeping. In fact, the competition has already introduced tens and hundreds of changes as we talk and talk. What we need 10 years for other countries to launch in a year. And here lies one of the biggest problems – realization and speed in following trends.Photo: Davor Rostuhar / Source: CNTBDoc. dr. sc. Dražen Čular from the Faculty of Kinesiology in Split, at this year’s 2nd International Congress of Sports Tourism, pointed out that sports tourism has no alternative, given the resources, potential and international recognition of Croatian athletes. It is sports tourism that needs to be recognized as the most strategically important form of tourism in Croatia and intensively developed in the future. It is necessary to find models and encourage product development in the field of sports tourism.We have everything, but again we have nothing. We have enough experts in all spheres from medical to marketing, we are a sports nation, we achieve top sports success, we have a great climate, we are unique through our diversity… Of course there are positive examples, mostly in Istria, but the general picture and conclusion is – there are pictures, no tons.See more about sports tourism at: LOUD THINKING: SPORTS TOURISM IN CROATIA – THERE ARE PICTURES, BUT NO TONE.
Comparison of camping prices in Kvarner and Istria
According to the annual traditional analysis of the portal Avtokampi.si, based on price analysis for the 2017 season, in 31 Kvarner camps the prices increased on average by 4,6%, and plots by the sea for a little less, 4,2%.Thus, the average price of “family camping” in Kvarner is 45,20 euros, and if the plot is directly on the sea, the price rises to 88,20 euros. According to the analysis, the lowest price a guest can pay for such family camping in the main season in Kvarner is 30,40 euros, and the most expensive is 75 euros.See the full analysis here ISTRIAN CAMPINGS INCREASED PLOTS BY 4% ON AVERAGE, AND THOSE BY THE SEA BY 9%Also, according to the portal analysis Avtokampi.si, based on price analysis for the 2017 season, in 30 Istrian camps the prices increased on average by 4,2% to 8,8% (main season on the plot, electricity, based on 2 adults + 2 children aged 4 and 11) . Thus, the average price of this “camping” in Istria is 49 euros, and if the plot is on the sea, the price rises to 61,40 euros.The lowest price that a guest can pay for such family camping in the main season in Istria is 35 euros, and the most expensive is 69 euros.CAPPELLI: LAW ON TOURIST LAND IS MY ABSOLUTE PRIORITYOne of the major problems and obstacles to better and faster development of camps are the way and conditions for obtaining a concession on tourist land in camps co-owned by the Republic of Croatia. The problem, which has been talked about for years, will be solved, but according to the announcements of the Minister of Tourism, who points out that the Law on Tourist Land is one of his main priorities, maybe the camps will soon get the wind in their sails. “The Law on Tourist Land is my absolute priority because it is of great importance for further intensification of investments needed to enable sustainable growth of tourism in the coming years. The submission of proposals for amendments to the Law on Tourist and Other Construction Land to the Government procedure is planned for the 4th quarter of this year. The expert holder of this law is the Ministry of State Property, and the Ministry of Tourism participates in the drafting of the Law with proposals following its experience in the implementation of the current law and the attitudes of the sector. Said Cappelli in an interview with HrTurizam.hr, in which, among other things, he announced a change in the functioning of the Main Office of the CNTB as well as the Law on Tourist Boards.Related news:ADAC: CROATIA TAKES 6TH PLACE IN THE EXPENSION OF CAMPSITES IN EUROPECAMP “MON PERIN” AS AN EXCELLENT EXAMPLE OF A SUCCESS CAMP STORYCAMP POLIDOR GREAT TOURIST STORY OF A SMALL FAMILY CAMP